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Autoimmune Diseases and ICD-10

Autoimmune diseases cause the body to produce antibodies that attack its own tissues, leading to deterioration, and in some cases destruction, of tissue.

Many autoimmune diseases that carry a higher risk to the patient’s health are defined in ICD-10 nomenclature, but codes are not narrowed down to one particular section.

Type 1 Diabetes

Age can be misleading with Type 1 diabetes. Don’t let a patient’s age determine your code selection since either type of diabetes can occur at almost any age. You should also remember that diabetes can come with multiple complications, and ICD-10 guidelines let you use as many codes within a particular category as you need to accurately indicate an individual’s health status.

When coding diabetes with manifestations, make sure you assign the appropriate additional digits needed to identify the type of complication.

ICD-10 Code


E10.1 – E10.11

Type 1 diabetes mellitus with ketoacidosis with or without coma

E10.2 – E10.29

Type 1 diabetes mellitus with kidney complications

E10.3 – E10.37

Type 1 diabetes mellitus with ophthalmic complications


Type 1 diabetes mellitus with other diabetic ophthalmic complication

E10.5 – E10.59

Type 1 diabetes mellitus with circulatory complications

E10.6 – E10.69

Type 1 diabetes mellitus with other specified complication

E85.0 – E85.9


Heart Conditions

If there is a causal relationship between hypertension and a heart condition, a code from I50.- or I51.4-I51.9 must be assigned to a code from category I11 (Hypertensive heart disease). If there is no causal relationship between hypertension and the heart condition, they must be coded separately. Sequence the codes according to the circumstances of the encounter.

ICD-10 Code



Dressler’s syndrome


Autoimmune myocarditis

Other Risk-Adjusted Autoimmune Conditions

ICD-10 Code


Coding Guidelines

D59.0*, D59.1- D68.61

Severe Hematological Disorders

*Use additional code for adverse effect, if applicable identify drug (T36-T50 with fifth or sixth character 5)

D89.82, D89.89*

Disorders of Immunity

*Excludes human immunodeficiency virus disease (B20)

G35, G36.0

Multiple Sclerosis


G37.3, G90.1

Spinal Cord Disorders


G61.0, G61.81, G70.00, G70.01, G70.80, G70.81, G73.1*, G72.41

Myasthenia Gravis, Myoneural Disorders, and Guillain-Barre Syndrome, Inflammatory and Toxic Neuropathy

*Code first underlying neoplasm (C00-D49)

K50.00 – K50.919, K51.80 – K51.919

Inflammatory Bowel Disease

Use additional code to identify any manifestations


Cirrhosis of Liver

Code also, if applicable, viral hepatitis (acute)(chronic)(B15-B19)


Autoimmune Hepatitis



Chronic Pancreatitis


ICD-10-CM Official Guidelines for Coding and Reporting
MedlinePlus Autoimmune Diseases